Formaldehyde → HCID 66590530, compound

Participants

Reaction Conditions

Reaction Steps

Formaldehyde (4.08 g, 50.2 mmol) was dissolved in methanol (2.032 mL, 50.2 mmol). The reaction was cooled to 0° C. (ice bath) and N-(3-(trifluoromethyl)benzyl)-1-(trimethylsilyl)methanamine (Example 56A, 10.94 g, 41.9 mmol) was added dropwise via addition funnel over 30 minutes. Potassium carbonate (4.63 g, 33.5 mmol) was added, and the mixture was stirred at 0° C. for 2 hours. The reaction solution was decanted from the potassium carbonate. The solution was treated with more potassium carbonate and decanted again. The potassium carbonate solids were sequentially washed with ether and these washes were added to the reaction solution. The solvent was removed in vacuo to give the title compound.

Provenance & Evidence