Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triacetoxyperiodinane → 2-(2-Oxo-3,3-diphenylpyrrolidin-1-yl)acetaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triacetoxyperiodinane | HCID 159087 | — |
| 반응물 | 1-(2-Hydroxyethyl)-3,3-diphenylpyrrolidin-2-one | HCID 67357537 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-(2-Oxo-3,3-diphenylpyrrolidin-1-yl)acetaldehyde | HCID 86640836 | — |
반응 단계
To a solution of Dess-Martin periodinane (8.03 g, 18.92 mmol) in dichloromethane (100 mL) was added a solution of the product from Example 67A (4.84 g, 17.20 mmol) in dichloromethane (50 mL) at room temperature. After 30 minutes at room temperature, the reaction is diluted with diethyl ether, filtered and concentrated. Chromatography eluting with a gradient of 50% to 100% ethyl acetate/hexanes using a SF25-40 g (Analogix®, Burlington, Wis.) column gave the title compound. MS (DCI+) m/z 280.1 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08044069B2 |
| 출처 데이터셋 | uspto-grants-2011_10 |
| ORD ID | ord-17835fdea9d24958b018468383893b7f |
| 출처 메모 | uspto-grants-2011_10 |