1-Benzyl-3-methylpyrrolidin-3-amine dihydrochloride → N-(1-benzyl-3-methylpyrrolidin-3-yl)-2-(2-oxo-3,3-diphenylpiperidin-1-yl)acetamide

Participants

Reaction Steps

The title compound was prepared as described in Example 28B reacting 2-(2-oxo-3,3-diphenylpiperidin-1-yl)acetic acid (Example 68E) with 1-benzyl-3-methylpyrrolidin-3-amine dihydrochloride. (CAS 181114-76-1). 1H NMR (300 MHz, CDCl3) δ ppm 7.33 (m, 15H), 4.08 (d, J=14.67 Hz, 2H), 4.00 (m, 2H), 3.81 (m, 2H), 3.51 (m, 2H), 3.25 (m, J=2.38 Hz, 1H), 3.05 (d, J=13.88 Hz, 1H), 2.67 (m, 2H), 2.26 (m, 2H), 1.85 (m, 2H), 1.49 (s, 3H); MS (ESI+) m/z 482 (M+H)+.

Provenance & Evidence