Hydrochloric Acid → HCID 45275163, compound

Participants

Reaction Steps

The compound from Example 101D (0.24 g, 0.42 mmol) was dissolved in methanol and treated with 4 N HCl in dioxane at ambient temperature for 2 hours. The reaction mixture was concentrated and then partitioned in 1 N NaOH/methylene chloride. The organic layer was dried over MgSO4, concentrated in vacuo and chromatographed, eluting with 5% MeOH/methylene chloride to yield the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 7.15-7.48 (m, 15H), 4.30-4.44 (m, 3H), 3.91-4.27 (m, 2H), 3.33-3.55 (m, 4H), 2.80-3.07 (m, 4H), 2.23-2.34 (m, 4H); MS (ESI+) m/z 469 (M+H)+.

Provenance & Evidence