HCID 67358657, compound → HCID 53391432, compound

HRID 1667194Notes

Reaction equation

HRID 1667194 reaction equation
C([N:8]1[CH2:39][CH2:38][C:11]2([CH2:14][N:13]([C:15](=[O:37])[CH2:16][N:17]3[CH2:21][CH2:20][C:19]([C:29]4[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=4)([C:22]4[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=4)[C:18]3=[O:36])[CH2:12]2)[CH2:10][CH2:9]1)C1C=CC=CC=1>C(O)C>[F:35][C:32]1[CH:33]=[CH:34][C:29]([C:19]2([C:22]3[CH:23]=[CH:24][C:25]([F:28])=[CH:26][CH:27]=3)[CH2:20][CH2:21][N:17]([CH2:16][C:15](=[O:37])[N:13]3[CH2:14][C:11]4([CH2:10][CH2:9][NH:8][CH2:39][CH2:38]4)[CH2:12]3)[C:18]2=[O:36])=[CH:30][CH:31]=1

Participants

3

Reactant 1

HCID 67358657HCID 67358657, compound

Product 1

HCID 53391432HCID 53391432, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

1-(2-(7-Benzyl-2,7-diazaspiro[3.5]nonan-2-yl)-2-oxoethyl)-3,3-bis(4-fluorophenyl)pyrrolidin-2-one (Example 152, 0.185 g, 0.349 mmol) and ethanol (20 mL) were added to 20% Pd(OH)2—C, wet (0.037 g, 0.263 mmol) in a 50 mL pressure bottle and stirred for 1 hour at 30 psi and 50° C. The mixture was filtered through a nylon membrane and concentrated to give the title compound.

Workup

  1. filtrationThe mixture was filtered through a nylon membrane
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-4fc6a81fa06f4069aefa07e81a5774b2
Source dataset
uspto-grants-2011_10
Patent number
US08044069B2

Reaction notes

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