1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → HCID 67443249, compound

Participants

Reaction Steps

A solution of N1-((ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine hydrochloride (0.049 g, 0.254 mmol), 2-(2-oxo-3,3-diphenylpyrrolidin-1-yl)acetic acid (0.050 g, 0.169 mmol; Example 1C) and oxazol-2-ylmethanamine (0.018 g, 0.186 mmol) were stirred together in dichloromethane (0.5 mL) at room temperature. After stirring overnight, the reaction was loaded directly onto a SF15-12 (Analogix®) column and the product eluted using a gradient of 5% to 100% ethyl acetate/hexanes over 20 minutes (Flow=30 mL/minute) to give the title compound. 1H NMR (300 MHz, CDCl3) δ 7.58 (s, 1H), 7.38-7.19 (m, 10H), 7.05 (s, 1H), 6.68 (s, 1H), 4.48 (d, J=5.6, 2H), 4.08 (s, 2H), 3.53 (t, J=6.5, 2H), 2.83 (t, J=6.5, 2H); MS (ESI+) m/z 376.0 (M+H)+.

Provenance & Evidence