Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3,3-Diphenylpyrrolidine → 1-{2-[3,3-Bis(4-fluorophenyl)pyrrolidin-1-yl]-2-oxoethyl}-3,3-diphenylpyrrolidin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3,3-Diphenylpyrrolidine | HCID 418242 | — |
| 반응물 | 2-(2-Oxo-3,3-diphenylpyrrolidin-1-yl)acetic acid | HCID 67359013 | — |
| 반응물 | 2-(3,3-Bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetic acid | HCID 67359111 | — |
| 반응물 | 3,3-Bis(4-fluorophenyl)pyrrolidine | HCID 67360178 | — |
| 생성물 | 1-{2-[3,3-Bis(4-fluorophenyl)pyrrolidin-1-yl]-2-oxoethyl}-3,3-diphenylpyrrolidin-2-one | HCID 67358672 | — |
반응 단계
The title compound was prepared using the procedure described in Example 172 substituting 2-(2-oxo-3,3-diphenylpyrrolidin-1-yl)acetic acid from Example 1C for 2-(3,3-bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetic acid and 3,3-bis(4-fluorophenyl)pyrrolidine from Example 203A for 3,3-diphenylpyrrolidine. 1H NMR (300 MHz, CDCl3) δ ppm 7.44-6.86 (m, 18H), 4.27-3.98 (m, 4H), 3.55 (dq, J=6.7, 9.6, 3H), 3.41 (t, J=6.7, 1H), 2.82 (q, J=6.5, 2H), 2.50 (dt, J=6.8, 21.3, 2H); MS (DCI) m/z 537.2 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08044069B2 |
| 출처 데이터셋 | uspto-grants-2011_10 |
| ORD ID | ord-94fdd312be52419e84de0d1b59700d2b |
| 출처 메모 | uspto-grants-2011_10 |