反应详情

The title compound was prepared using the procedure described in Example 172 substituting 2-(3,3-bis(4-fluorophenyl)-2-oxopyrrolidin-1-yl)acetic acid from Example 58D for 2-(3,3-bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetic acid and 3,3-bis(4-fluorophenyl)pyrrolidine from Example 203A for 3,3-diphenylpyrrolidine. 1H NMR (300 MHz, CDCl3) δ ppm 7.38-7.28 (m, 4H), 7.18-7.09 (m, 4H), 7.03-6.93 (m, 8H), 4.11 (dd, J=5.1, 9.1, 4H), 3.61-3.48 (m, 3H), 3.42 (t, J=6.7, 1H), 2.77 (dd, J=6.4, 11.7, 2H), 2.57 (t, J=6.7, 1H), 2.47 (t, J=6.9, 1H); MS (DCI) m/z 573.2 (M+H)+.