3,3-Diphenylpyrrolidine → 1-{2-[3,3-Bis(4-fluorophenyl)pyrrolidin-1-yl]-2-oxoethyl}-3,3-diphenylpiperidin-2-one
反応式
[O:1]=[C:2]1[C:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:6][CH2:5][CH2:4][N:3]1[CH2:20][C:21](O)=[O:22].FC1C=CC(C2(C3C=CC(F)=CC=3)CCCN(CC(O)=O)C2=O)=CC=1.[F:49][C:50]1[CH:55]=[CH:54][C:53]([C:56]2([C:61]3[CH:66]=[CH:65][C:64]([F:67])=[CH:63][CH:62]=3)[CH2:60][CH2:59][NH:58][CH2:57]2)=[CH:52][CH:51]=1.C1(C2(C3C=CC=CC=3)CCNC2)C=CC=CC=1>>[F:49][C:50]1[CH:55]=[CH:54][C:53]([C:56]2([C:61]3[CH:66]=[CH:65][C:64]([F:67])=[CH:63][CH:62]=3)[CH2:60][CH2:59][N:58]([C:21](=[O:22])[CH2:20][N:3]3[CH2:4][CH2:5][CH2:6][C:7]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)([C:8]4[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=4)[C:2]3=[O:1])[CH2:57]2)=[CH:52][CH:51]=1参加物
5
反応物 4
生成物 1
実験手順
The title compound was prepared using the procedure described in Example 172 substituting 2-(2-oxo-3,3-diphenylpiperidin-1-yl)acetic acid from Example 68E for 2-(3,3-bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetic acid and 3,3-bis(4-fluorophenyl)pyrrolidine from Example 203A for 3,3-diphenylpyrrolidine. 1H NMR (300 MHz, CDCl3) δ ppm 7.30 (d, J=4.4, 8H), 7.25-7.21 (m, 2H), 7.17-7.10 (m, 4H), 6.98-6.88 (m, 4H), 4.14-4.07 (m, 4H), 3.67-3.45 (m, 4H), 2.70-2.60 (m, 2H), 2.55 (t, J=6.7, 1H), 2.45 (t, J=6.8, 1H), 1.90-1.78 (m, 2H); MS (DCI) m/z 551.2 (M+H)+.
出典と根拠
- ORDレコード
- ord-0bc9d2e91a24414c9e12145777e471c2
- 出典データセット
- uspto-grants-2011_10
- 特許番号
- US08044069B2
反応ノート
読み込み中…