N'-Hydroxy-4-(trifluoromethyl)benzene-1-carboximidamide → HCID 86640840, compound

Participants

Reaction Steps

The title compound was prepared using the procedure described in Example 190 substituting 2-(2-oxo-3,3-diphenylpyrrolidin-1-yl)acetic acid from Example 1C for 2-(3,3-bis(4-fluorophenyl)-2-oxopyrrolidin-1-yl)acetic acid and (Z)-6-chloro-N-hydroxynicotinimidamide for (Z)—N-hydroxy-4-(trifluoromethyl)benzimidamide. 1H NMR (300 MHz, CDCl3) δ ppm 9.00 (dd, J=0.7, 2.4, 1H), 8.21 (dd, J=2.4, 8.3, 1H), 7.45 (dd, J=0.7, 8.4, 1H), 7.38-7.24 (m, 10H), 4.90 (s, 2H), 3.58 (t, J=6.5, 2H), 2.90 (t, J=6.5, 2H); MS (DCI) m/z 431.1 (M+H)+.

Provenance & Evidence