N'-Hydroxy-4-(trifluoromethyl)benzene-1-carboximidamide → HCID 67377687, compound

HRID 1667251Notes

Reaction equation

HRID 1667251 reaction equation
[O:1]=[C:2]1[C:6]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[CH2:5][CH2:4][N:3]1[CH2:19][C:20]([OH:22])=O.FC1C=CC(C2(C3C=CC(F)=CC=3)CCN(CC(O)=O)C2=O)=CC=1.[F:47][C:48]1[CH:49]=[C:50]([CH:56]=[C:57]([F:59])[CH:58]=1)/[C:51](=[N:54]/[H])/[NH:52]O.ON/C(=N\[H])/C1C=CC(C(F)(F)F)=CC=1>>[F:47][C:48]1[CH:49]=[C:50]([C:51]2[N:54]=[C:20]([CH2:19][N:3]3[CH2:4][CH2:5][C:6]([C:7]4[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=4)([C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=4)[C:2]3=[O:1])[O:22][N:52]=2)[CH:56]=[C:57]([F:59])[CH:58]=1

Participants

5

Reactant 4

HCID 609329N'-Hydroxy-4-(trifluoromethyl)benzene-1-carboximidamideHCID 673571912-(3,3-Bis(4-fluorophenyl)-2-oxopyrrolidin-1-yl)acetic acidHCID 673590132-(2-Oxo-3,3-diphenylpyrrolidin-1-yl)acetic acidHCID 178506514HCID 178506514, compound

Product 1

HCID 67377687HCID 67377687, compound

Procedure

The title compound was prepared using the procedure described in Example 190 substituting 2-(2-oxo-3,3-diphenylpyrrolidin-1-yl)acetic acid from Example 1C for 2-(3,3-bis(4-fluorophenyl)-2-oxopyrrolidin-1-yl)acetic acid and (Z)-3,5-difluoro-N-hydroxybenzimidamide for (Z)—N-hydroxy-4-(trifluoromethyl)benzimidamide. 1H NMR (300 MHz, CDCl3) δ ppm 7.56-7.49 (m, 2H), 7.42-7.24 (m, 10H), 7.01-6.91 (m, 1H), 4.89 (s, 2H), 3.57 (t, 2H), 2.90 (t, J=6.5, 2H); MS (DCI) m/z 432.1 (M+H)+.

Sources & evidence

ORD record
ord-11e012767f8b4bfea395ec14fa00361a
Source dataset
uspto-grants-2011_10
Patent number
US08044069B2

Reaction notes

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