N'-Hydroxy-4-(trifluoromethyl)benzene-1-carboximidamide → HCID 45274311, compound

Participants

Reaction Steps

The title compound was prepared using the procedure described in Example 190 substituting 2-(2-oxo-3,3-diphenylpyrrolidin-1-yl)acetic acid from Example 1C for 2-(3,3-bis(4-fluorophenyl)-2-oxopyrrolidin-1-yl)acetic acid and (Z)-tert-butyl 5-(N-hydroxycarbamimidoyl)pyridin-2-ylcarbamate for (Z)—N-hydroxy-4-(trifluoromethyl)benzimidamide. 1H NMR (300 MHz, CDCl3) δ ppm 8.85 (d, J=1.7, 1H), 8.22 (dd, J=2.2, 8.8, 1H), 8.07 (d, J=8.8, 1H), 7.48-7.28 (m, 10H), 4.89 (s, 2H), 3.57 (t, J=6.5, 2H), 2.89 (t, J=6.5, 2H), 1.55 (s, 9H); MS (DCI) m/z 512.2 (M+H)+.

Provenance & Evidence