1,2,3,4-Tetrahydroisoquinoline → HCID 45274408, compound

Participants

Reaction Steps

The title compound was prepared using the procedure described in Example 172 substituting 2-(3-(4-fluorophenyl)-2-oxopyrrolidin-1-yl)acetic acid from Example 216A for 2-(3,3-bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetic acid and 1,2,3,4-tetrahydroisoquinoline for 3,3-diphenylpyrrolidine. 1H NMR (300 MHz, CDCl3) δ ppm 7.35-6.96 (m, 8H), 4.68 (d, J=27.4, 2H), 4.34 (d, 1H), 4.19 (dd, J=7.4, 15.9, 1H), 3.84 (t, J=6.0, 1H), 3.78-3.52 (m, 4H), 3.02-2.81 (m, 2H), 2.68-2.45 (m, 1H), 2.25-2.06 (m, 1H); MS (DCI) m/z 353.1 (M+H)+.

Provenance & Evidence