反应详情

The title compound was prepared using the procedure described in Example 172 substituting 2-(3-(4-fluorophenyl)-2-oxopyrrolidin-1-yl)acetic acid from Example 216A for 2-(3,3-bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetic acid and 7-fluoro-1,2,3,4-tetrahydroisoquinoline for 3,3-diphenylpyrrolidine. 1H NMR (300 MHz, CDCl3) δ ppm 7.36-7.20 (m, 2H), 7.16-6.96 (m, 3H), 6.95-6.75 (m, 2H), 4.66 (d, J=26.3, 2H), 4.34 (d, J=16.0, 1H), 4.22-4.03 (m, 1H), 3.83 (dd, J=5.7, 11.4, 1H), 3.75-3.49 (m, 4H), 2.87 (dd, J=5.8, 11.7, 2H), 2.68-2.45 (m, 1H), 2.16 (dd, J=7.7, 13.2, 1H)); MS (DCI) m/z 371.1 (M+H)+.