3,3-Diphenylpyrrolidine → 1-[2-(7-chloro-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-3-(4-fluorophenyl)pyrrolidin-2-one

関与物質

反応手順

The title compound was prepared using the procedure described in Example 172 substituting 2-(3-(4-fluorophenyl)-2-oxopyrrolidin-1-yl)acetic acid from Example 216A for 2-(3,3-bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetic acid and 7-chloro-1,2,3,4-tetrahydroisoquinoline for 3,3-diphenylpyrrolidine. 1H NMR (300 MHz, CDCl3) δ ppm 7.37-7.20 (m, 2H), 7.21-6.93 (m, 5H), 4.65 (d, J=26.2, 2H), 4.33 (d, J=15.9, 1H), 4.24-4.00 (m, 1H), 3.82 (t, 1H), 3.76-3.48 (m, 4H), 2.86 (dt, J=5.9, 11.4, 2H), 2.57 (d, J=3.8, 1H), 2.16 (dd, J=6.2, 14.6, 1H); MS (DCI) m/z 387.1 (M+H)+.

情報源と証拠