3,3-Diphenylpyrrolidine → HCID 67376937, compound

Participants

Reaction Steps

The title compound was prepared using the procedure described in Example 172 substituting 2-(3-(4-fluorophenyl)-2-oxopyrrolidin-1-yl)acetic acid from Example 216A for 2-(3,3-bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetic acid and 6-chloro-1,2,3,4-tetrahydroisoquinoline for 3,3-diphenylpyrrolidine. 1H NMR (300 MHz, CDCl3) δ ppm 7.41-7.11 (m, 4H), 7.03 (ddd, J=6.1, 10.3, 12.6, 3H), 4.65 (d, J=24.0, 2H), 4.33 (d, 1H), 4.21-4.04 (m, 1H), 3.89-3.44 (m, 5H), 2.87 (dt, J=5.9, 11.7, 2H), 2.66-2.44 (m, 1H), 2.23-2.04 (m, 1H); MS (DCI) m/z 387.1 (M+H)+.

Provenance & Evidence