1,2,3,4-Tetrahydroisoquinoline → HCID 67377456, compound

Participants

Reaction Steps

The title compound was prepared using the procedure described in Example 172 substituting 2-(3,3-bis(4-fluorophenyl)-2-oxopyrrolidin-1-yl)acetic acid from Example 58D for 2-(3,3-bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetic acid and 1,2,3,4-tetrahydroisoquinoline for 3,3-diphenylpyrrolidine. 1H NMR (300 MHz, CDCl3) δ ppm 7.31 (dt, J=4.4, 5.5, 4H), 7.22-7.11 (m, 3H), 7.06-6.94 (m, 5H), 4.75-4.53 (m, 2H), 4.27 (d, J=4.8, 2H), 3.82 (t, J=6.0, 1H), 3.65 (t, J=6.0, 1H), 3.52 (q, J=6.5, 2H), 2.91-2.67 (m, 4H); MS (DCI) m/z 447.1 (M+H)+.

Provenance & Evidence