3,3-Diphenylpyrrolidine → HCID 67377240, compound

Participants

Reaction Steps

The title compound was prepared using the procedure described in Example 172 substituting 2-(3,3-bis(4-fluorophenyl)-2-oxopyrrolidin-1-yl)acetic acid from Example 58D for 2-(3,3-bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetic acid and 7-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline for 3,3-diphenylpyrrolidine. 1H NMR (300 MHz, CDCl3) δ ppm 7.51-7.35 (m, 2H), 7.36-7.21 (m, 5H), 6.98 (td, J=5.3, 8.6, 4H), 4.70 (d, J=35.4, 2H), 4.27 (s, 2H), 3.83 (t, J=6.0, 1H), 3.68 (t, J=5.9, 1H), 3.53 (t, J=6.5, 2H), 2.88 (dd, J=8.0, 13.3, 2H), 2.81-2.73 (m, 2H); MS (DCI) m/z 515.1 (M+H)+.

Provenance & Evidence