反应详情

The title compound was prepared using the procedure described in Example 172 substituting 2-(2-oxo-3-(4-(trifluoromethyl)phenyl)pyrrolidin-1-yl)acetic acid from Example 266D for 2-(3,3-bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetic acid and 5-fluoroisoindoline for 3,3-diphenylpyrrolidine. 1H NMR (300 MHz, CDCl3) δ ppm 7.61 (d, J=8.2, 2H), 7.46 (d, J=8.2, 2H), 7.32-7.16 (m, 1H), 7.06-6.89 (m, 2H), 4.82 (dd, J=8.7, 15.1, 4H), 4.34-4.13 (m, 2H), 3.83 (t, J=8.9, 1H), 3.77-3.60 (m, 2H), 2.72-2.53 (m, 1H), 2.22 (ddd, J=8.5, 12.9, 16.1, 1H); MS (DCI) m/z 407.1 (M+H)+.