tert-Butyl 4-formylpiperidine-1-carboxylate → HCID 10335872, compound

Participants

Reaction Steps

As starting materials, 5.00 g of (2,6-dimethylbenzyl)(triphenyl)phosphonium chloride and 1.79 g of tert-butyl 4-formylpiperidine-1-carboxylate were used and treated in the same manner as in Example 1. The reaction mixture was then purified by silica gel column chromatography (hexane-ethyl acetate) to give 192 mg of tert-butyl 4-[(Z)-2-(2,6-dimethylphenyl)vinyl]piperidine-1-carboxylate (Example 2-1) and 1.96 g of tert-butyl 4-[(E)-2-(2,6-dimethylphenyl)vinyl]piperidine-1-carboxylate (Example 2-2).

Provenance & Evidence