Hydrochloric Acid → HCID 10061752, compound

Participants

Reaction Steps

After 3 ml of 10% hydrochloric acid was added to a solution of 818 mg of 4-[(E)-2-(2,6-dimethylphenyl)vinyl]-1-(1,3-dioxolane-2-ylmethyl)piperidin-2-one in 10 ml of tetrahydrofuran, the mixture was heated under reflux for 4.5 hours. After cooling, the reaction mixture was poured into saturated aqueous sodium hydrogen carbonate solution and extracted with ethyl acetate. The organic layer was washed with water and saturated aqueous sodium chloride. After drying over anhydrous sodium sulfate, the solvent was evaporated under reduced pressure to give 685 mg of {4-[(E)-2-(2,6-dimethylphenyl)vinyl]-2-oxopiperidin-1-yl}acetaldehyde.

Provenance & Evidence