反应详情

Combine 2-amino-6-(1-methylpiperidin-4-ylcarbonyl)pyridine (0.18 g, 0.85 mmol), 2-chloro-6-fluoro-benzoyl chloride (0.318 g, 1.65 mmol), and 1,4-dioxane (10 mL). Stir and heat the mixture at reflux. After 2 hr., cool the reaction mixture to ambient-temperature and concentrate. Load the mixture onto an SCX column (10 g), wash with methanol, and elute with 2M ammonia/methanol. Concentrate the eluent to obtain the free base of the title compound (0.30 g, 94%) as an oil. Dissolve the oil in methanol (5 mL) and treat with ammonium chloride (0.045 g, 0.85 mmol). Concentrate the mixture and dry under vacuum to obtain the title compound. HRMS Obs. m/z 376.1237; Calc. m/z 376.1228. m.p. 155° C. (dec).

1. temperatureheat the mixture
2. temperatureat reflux
3. temperature, cool the reaction mixture to ambient-temperature and
4. concentrationconcentrate
5. washLoad the mixture onto an SCX column (10 g), wash with methanol
6. washelute with 2M ammonia/methanol
7. concentrationConcentrate the eluent