Hydrochloric Acid → HCID 57658324, compound

Participants

Reaction Steps

To a solution of 6-amino-1-[4-(1,4-dioxa-spiro[4.5]dec-8-yloxy)-2,6-difluoro-phenyl]-5-(4-fluorobenzoyl)-1H-pyridin-2-one (0.55 g, 1.10 mmol) in 1,4-dioxane (10 ml) was added 2M aq HCl (5 ml) at room temperature. Stirring was continued for 18 h. Upon completion of reaction the reaction mixture was diluted with water (10 ml) before evaporation of dioxane under reduced pressure. The residual aqueous solution was extracted with EtOAc (2×10 ml). The combined organic layers were dried (Na2SO4), filtered and concentrated to dryness under reduced pressure to give the desired ketone as a white solid (0.43 g, 86%). LCMS purity 98%, m/z 457 [M+H]+, 1H NMR (400 MHz, CDCl3), δ: 2.05-2.15 (2H, m), 2.25-2.45 (4H, m), 2.55-2.70 (2H, m), 4.65-4.75 (1H, m), 5.85 (1H, d), 6.70-6.75 (2H, m), 7.05-7.15 (2H, m), 7.50-7.65 (3H, m),

Provenance & Evidence