L-Leucine ethyl ester → Ethyl N-(3-{4-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenoxy}propyl)-L-leucinate

Participants

Role	Name	HCID	Charge
Reactant	L-Leucine ethyl ester	HCID 75971	—
Reactant	Methanesulfonic acid 3-{4-[6-amino-5-(4-fluorobenzoyl)-2-oxo-2H-pyridin-1-yl]-3,5-difluorophenoxy}-propyl ester	HCID 57658362	—
Product	Ethyl N-(3-{4-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenoxy}propyl)-L-leucinate	HCID 57658386	—

Reaction Steps

From Intermediate 4E and L-leucine ethyl ester LCMS purity 98%, m/z 560 [M+H]+, 1H NMR (400 MHz, CD3OD), δ: 1.10-1.20 (6H, m), 1.45-1.55 (3H, t), 1.65-1.85 (2H, m), 1.90-2.00 (1H, m), 2.15-2.30 (2H, m), 2.85-3.05 (2H, m), 3.55 (1H, m), 4.35-4.50 (4H, m), 6.00 (1H, d), 7.10 (1H, d), 7.45-7.55 (1H, m), 7.80-7.85 (1H, m), 7.95 (1H, d).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08044211B2
Source dataset	uspto-grants-2011_10
ORD ID	ord-c280d596d1b4475db4384aca556835d9
Source note	uspto-grants-2011_10