(S)-cyclopentyl 2-amino-4-methylpentanoate → Cyclopentyl(S)-2-(3-{4-[6-Amino-5-(4-fluoro-3-methylbenzoyl)-2-oxo-2H-pyridin-1-yl]-3,5-difluorophenoxy}propylamino)-4-methylpentanoate

Participants

Reaction Steps

From Intermediate 4D and L-leucine cyclopentyl ester (Intermediate 8), LCMS purity 100%, m/z 614 [M+H]+, 1H NMR (400 MHz, d6-DMSO), δ: 0.90 (6H, m), 1.60-1.70 (10H, m), 1.90 (2H, m), 2.15 (2H, m), 2.30 (3H, s), 3.00-3.20 (2H, m), 4.10 (1H, s), 4.20 (2H, m), 5.25 (1H, m), 5.70 (1H, d), 7.05 (1H, d), 7.25 (1H, m), 7.40 (1H, m), 7.50 (1H, m), 7.60 (1H, d).

Provenance & Evidence