Sodium Iodide → HCID 24798259, compound

Participants

Reaction Conditions

Reaction Steps

From Intermediate 4G. To a solution of 6-Amino-1-{4-[(5-chloropentyl)oxy]-2,6-difluorophenyl}-5-(2,4-difluorobenzoyl)pyridin-2(1H)-one (138 mg, 0.29 mmol) in anhydrous DMF (3 ml) under an atmosphere of nitrogen was added cyclopentyl L-leucinate (Intermediate 8) (284 mg, 1.43 mmol, 5 eq), sodium iodide (86 mg, 0.57 mmol, 2 eq) and N,N-diisopropylethylamine (0.052 ml, 0.29 mmol, 1 eq). The mixture was heated at 90° C. for 16 hours, before being allowed to cool to room temperature and diluted with EtOAc (25 ml). The solution was washed with water (2×25 ml) and brine (25 ml). The organic layer was dried over MgSO4, filtered and concentrated under reduced pressure. Purification by column chromatography (3-4% MeOH in DCM) followed by preparative HPLC afforded the title compound as a cream coloured solid (96 mg, 52% yield).

Provenance & Evidence