(S)-cyclopentyl 2-amino-4-methylpentanoate → Cyclopentyl N-[2-(4-{6-amino-5-[(4-fluorophenyl)carbonyl]-2-oxopyridin-1(2H)-yl}phenyl)ethyl]-L-leucinate

Participants

Reaction Steps

From Intermediate 4J and L-Leucine cyclopentyl ester (Intermediate 8). LC/MS: m/z 534 [M+H]+. 1H NMR (300 MHz, DMSO-d6) δ: 8.47 (1H, d, J=7.7 Hz), 7.56 (2H, m), 7.45 (1H, d, J=9.6 Hz), 7.38-7.24 (4H, m), 7.15 (2H, m), 5.69 (1H, d, J=9.8 Hz), 5.09 (1H, t, J=5.3 Hz), 4.63 (2H, m), 4.31 (1H, m), 1.84-1.79 (2H, m), 1.66-1.53 (9H, m), 0.92-0.86 (6H, m).

Provenance & Evidence