HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Leucine → tert-Butyl N-[2-(4-{6-amino-5-[(4-fluorophenyl)carbonyl]-2-oxopyridin-1(2H)-yl}phenyl)ethyl]-L-leucinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Leucine | HCID 6106 | — |
| Reactant | Methanesulfonic acid 2-{4-[6-amino-5-(4-fluoro-benzoyl)-2-oxo-2H-pyridin-1-yl]-phenyl}-ethyl ester | HCID 58608538 | — |
| Product | tert-Butyl N-[2-(4-{6-amino-5-[(4-fluorophenyl)carbonyl]-2-oxopyridin-1(2H)-yl}phenyl)ethyl]-L-leucinate | HCID 57658410 | — |
Reaction Steps
From Intermediate 4J and L-Leucine tbutyl ester. LC/MS: m/z 522 [M+H]+. 1H NMR (300 MHz, DMSO-d6) δ: 9.40-9.10 (2H, m), 7.59-7.44 (5H, m), 7.38-7.30 (4H, m), 5.71 (1H, d, J=9.6 Hz), 4.00 (1H, brs), 3.40-3.28 (1H, m), 3.25-3.15 (1H, m), 3.10-3.00 (2H, m), 1.80-1.70 (3H, m), 0.96 (6H, d, J=5.1 Hz).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08044211B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-74e8d25a164b477885b4090320d270d7 |
| Source note | uspto-grants-2011_10 |