HCID 86620964, compound → HCID 24947590, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-dimethylamino-1-iodo-phthalazine-6-carboxylic acid (3-trifluoromethyl-phenyl)-amide (85 mg, 0.175 mmol), pyridine (3 mL) and CuCN (46 mg, 0.514 mmol) was heated to 85° C. for 2 h and concentrated. Column chromatography (Hexanes/EtOAc) afforded the desired compound (38 mg, 56.7%) as a yellow solid. 1H-NMR (CDCl3) δ: 3.44 (s, 6H), 7.30-7.34 (m, 1H), 7.42 (t, 1H), 8.00-8.04 (m, 2H), 8.07 (d, 1H), 8.66 (dd, 1H), 8.78 (s, 1H), 10.26 (bs, 1H). m/z (M+1) 386.20.

Provenance & Evidence