HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1667405Generated: October 30, 2026
Potassium Carbonate → (1,4-Dichloro-phthalazin-6-yl)-(3-trifluoromethyl-benzyl)-amine
https://huagongshe.com/reaction/1667405
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(Bromomethyl)-3-(trifluoromethyl)benzene | HCID 123061 | — |
| Reactant | 1,4-Dichlorophthalazin-6-amine | HCID 58447221 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (1,4-Dichloro-phthalazin-6-yl)-(3-trifluoromethyl-benzyl)-amine | HCID 86620966 | 26.3% |
Reaction Steps
A mixture of 1,4-dichloro-6-amino-phthalazine (33 mg, 0.154 mmol), K2CO3 (79 mg, 0.57 mmol), DMF (5 mL) and 3-(trifluoromethyl)benzyl bromide (2.0 mL, 0.17 mmol) were heated to 85° C. for 18 h. The reaction was cooled, poured onto water and extracted with EtOAc. The combined organic layers were washed with H2O, brine, dried (Na2SO4) and concentrated. Column chromatography (Hexanes/EtOAc) afforded the desired product (15 mg, 26.3%) as a yellow solid. m/z 372.08 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08044041B2 |
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| Source dataset | uspto-grants-2011_10 |
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| ORD ID | ord-bfe57511d1a941819d0591d30f326750 |
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| Source note | uspto-grants-2011_10 |
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