HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1667407Generated: October 31, 2026
Hydrazine hydrate (1:1) → 6-Bromophthalazin-1(2h)-one
https://huagongshe.com/reaction/1667407
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 5-Bromo-3-hydroxyisoindolin-1-one | HCID 11615537 | — |
| Product | 6-Bromophthalazin-1(2h)-one | HCID 11535918 | 46.6% |
Reaction Steps
A mixture of 5-bromo-3-hydroxy-2,3-dihydro-isoindol-1-one (15.75 g, 69.06 mmol) and hydrazine hydrate (70 mL, 1439.2 mmol) was heated at 95° C. for 5 h. The precipitate was filtered, washed with water and the crude material triturated with hot EtOAc to afford the product (7.25 g, 46.6%) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08044041B2 |
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| Source dataset | uspto-grants-2011_10 |
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| ORD ID | ord-0585b580b0574143ab35011c3d00c2fd |
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| Source note | uspto-grants-2011_10 |
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