Hydrogen Bromide → HCID 178522040, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-methoxy-4-pyridin-2-yl-phthalazine-6-carboxylic acid (3-trifluoromethyl-phenyl)-amide (57 mg, 0.134 mmol), dioxane (3 mL) and 48% HBr (4 mL) was stirred at 40° C. for 1.5 hours. Concentration followed by chromatography (Hex/EtOAc) afforded 1-hydroxy-4-pyridin-2-yl-phthalazine-6-carboxylic acid (3-trifluoromethyl-phenyl)-amide (56 mg) as a white solid, 1H NMR (400 MHz, 4:1 CDCl3:d6-DMSO) δ: 7.27 (d, 1H), 7.36-7.44 (m, 2H), 7.90-7.95 (m, 2H), 8.05 (s, 1H), 8.21 (s, 1H), 8.33 (dd, 1H), 8.47 (d, 1H), 8.65 (dd, 1H), 8.81 (d, 1H), 10.50 (s, 1H), 12.80 (s, 1H) ppm. m/z 410.96.

Provenance & Evidence