Ammonia → HCID 67416422, compound

Participants

Reaction Steps

A mixture of 2-((R)-3-methyl-piperazin-1-yl)-benzonitrile (542 mg, 2.69 mmol), Raney Nickel (3 mL of a slurry in water), ammonia (15 mL, 2M solution in EtOH) was evacuated and flushed with H2, then stirred at room temperature for 3 h. The reaction mixture was filtered through celite, rinsed with MeOH, concentrated and dried in vacuum to afford 2-((R)-3-methyl-piperazin-1-yl)-benzylamine (526 mg) as an orange viscous oil. m/z (M+1) 206.29.

Provenance & Evidence