HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 58996706, compound → HCID 67418563, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 58996706 | HCID 58996706 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol, reaction products with ammonia, distn. residues | HCID 22020343 | — |
| Product | HCID 67418563 | HCID 67418563 | 98.2% |
Reaction Steps
To a solution of 4-(2-cyano-phenyl)-perhydro-1,4-diazepine-1-carboxylic acid tert-butyl ester (905 mg, 3.0 mmol) in NH3/EtOH (2M, 15 mL) was added Raney Nickel (5 mL slurry in water). The atmosphere was exchanged with hydrogen via balloon and the mixture was allowed to stir for 2.5 h. After this time the mixture was filtered through celite and concentrated to yield the title compound (900 mg). m/z (M+1) 305.31.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08044041B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-9b76f59e05194271aedc68ec5b0f9047 |
| Source note | uspto-grants-2011_10 |