4-(2-Cyano-4-methoxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester → 4-(2-Aminomethyl-4-methoxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

HRID 1667539ノート

反応式

HRID 1667539 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][C:15]=2[C:22]#[N:23])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[H][H]>N.CCO.[Ni]>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][C:15]=2[CH2:22][NH2:23])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

参加物

5

反応物 2

HCID 674174064-(2-Cyano-4-methoxy-phenyl)-piperazine-1-carboxylic acid tert-butyl esterHCID 178418361HCID 178418361、化合物

生成物 1

HCID 674174384-(2-Aminomethyl-4-methoxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester収率 94.5%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 22020343Ethanol, reaction products with ammonia, distn. residues溶媒

実験手順

To a solution of 4-(2-cyano-4-methoxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (680 mg, 2.14 mmol) in NH3/EtOH (2M, 15 mL) was added Raney Nickel (5 mL slurry in water). The atmosphere was exchanged with hydrogen via balloon and the mixture was allowed to stir for 2.5 h. After this time the mixture was filtered through celite and concentrated to yield the title compound (650 mg). m/z (M+1) 321.57.

後処理

  1. filtrationAfter this time the mixture was filtered through celite and
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-a390b94b8a5a47ccb65a4b0a28887989
出典データセット
uspto-grants-2011_10
特許番号
US08044041B2

反応ノート

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