Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1-Chloro-6-methoxyisoquinoline | HCID 21901074 | — |
| Catalyst | HCID 178419072 | HCID 178419072 | — |
| Solvent | Ethylene Glycol | HCID 174 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 6-Methoxyisoquinolin-1-amine | HCID 15538409 | 72% |
Reaction Steps
A sealable tube was charged with 1J (770 mg, 3.98 mmol), copper (I) oxide (30 mg) and ˜12M ammonia in ethylene glycol (5 mL). The tube was sealed and the reaction was heated to 120° C. for 72 h. After cooling to rt, the reaction was diluted with methanol and was purified via preparative HPLC (MeOH/water/TFA) to provide 1K (832 mg, 72%). LC-MS: 175.23 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08044242B2 |
|---|
| Source dataset | uspto-grants-2011_10 |
|---|
| ORD ID | ord-8d6c57b656764fa08ad15481e55093b2 |
|---|
| Source note | uspto-grants-2011_10 |
|---|
