HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-(Ethylsulfanyl)-5-nitrobenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ethanethiol | HCID 6343 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Fluoro-5-nitrobenzonitrile | HCID 519417 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(Ethylsulfanyl)-5-nitrobenzonitrile | HCID 57448181 | 97% |
Reaction Steps
To 2-fluoro-5-nitrobenzonitrile (5.00 g, 30.1 mmol) in DMF (100 mL), triethylamine (9.30 mL, 66.7 mmol) was added and followed by ethanethiol (2.80 mL, 37.9 mmol). After stirring at rt for 1 h, the reaction mixture was poured into water (500 mL). The resulting precipitate was filtered and dried on high vacuum overnight to provide 5A (6.08 g, 97%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08044242B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-5f3dacf6515e4129bb8d17bfe3f7bf5d |
| Source note | uspto-grants-2011_10 |