HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-[3-Cyano-4-(ethanesulfonyl)phenyl]acetamide → N-(3-(Aminomethyl)-4-(ethylsulfonyl)phenyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-[3-Cyano-4-(ethanesulfonyl)phenyl]acetamide | HCID 57448183 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-(3-(Aminomethyl)-4-(ethylsulfonyl)phenyl)acetamide | HCID 57448184 | 93.9% |
Reaction Steps
To 5C (423 mg, 1.65 mmol) in MeOH (17 mL), Raney Ni (cat) was added. The mixture was stirred under hydrogen (60 psi) for 8 h, then filtered and concentrated to provide 5D (397 mg, 92%). LC-MS: 253.23 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08044242B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-8077cd3d37524dee9a4260f1c487a12c |
| Source note | uspto-grants-2011_10 |