1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 57448194, compound

Participants

Reaction Steps

To 8B (190 mg, 0.89 mmol) in THF (5 mL) at 0° C. was added DPPA (300 mg, 1.1 mmol) in THF (1 mL) and DBU (170 mg, 1.9 mmol). The cold bath was removed and the reaction was stirred at rt overnight. The reaction was then concentrated and purified via silica gel chromatography (0-15% ethyl acetate/hexane) to provide 8C (160 mg, 90%) and starting material (8B) (30 mg). 8C: LC-MS: 237.16 (M+H)+.

Provenance & Evidence