Hydrochloric Acid → HCID 140536906, compound

Participants

Reaction Steps

To 9D (570 mg, 1.09 mmol) in THF (6.0 mL) and MeOH (0.5 mL) was added LiOH (1.0 M, 1.92 mL, 1.92 mmol). The mixture was stirred at rt for 1.0 h before it was acidified with 1.0 N HCl (5.0 mL). The mixture was extracted with ethyl acetate, washed with brine and dried over Na2SO4. After removal of solvent, 9E (500 mg, 90% yield) was obtained as a white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.23 (d, J=6.16 Hz, 6H) 1.30 (t, J=7.03 Hz, 3H) 4.00 (q, J=7.03 Hz, 2H) 4.49 (m, 1H) 5.09 (s, 2H) 5.85 (s, 1H) 6.90-7.38 (m, 11H) 7.95 (d, J=9.20 Hz, 2H).

Provenance & Evidence