HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Isopropylsulfonyl)-5-nitrobenzonitrile → 5-Amino-2-(isopropylsulfonyl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Isopropylsulfonyl)-5-nitrobenzonitrile | HCID 57448206 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-Amino-2-(isopropylsulfonyl)benzonitrile | HCID 57448207 | 98% |
Reaction Steps
To 2-(isopropylsulfonyl)-5-nitrobenzonitrile (15B) (1.26 g, 4.96 mmol) in THF (20 mL) was added Pd/C (cat.) and the mixture was hydrogenated at 50 psi overnight. The reaction was filtered to provide 15C (1.09 g). LC-MS: 225.3 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08044242B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-ca001710f8b740baba3b47db7d46c0c7 |
| Source note | uspto-grants-2011_10 |