HCID 24804837, compound → HCID 24804838, compound

HRID 1667639Notes

Reaction equation

HRID 1667639 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=2)=[CH:11][C:10]=1/[CH:26]=[CH:27]/[C:28]([OH:30])=[O:29])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Pt]=O.C(O)C>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([O:21][C:22]([F:24])([F:25])[F:23])=[CH:17][CH:16]=2)=[CH:11][C:10]=1[CH2:26][CH2:27][C:28]([OH:30])=[O:29])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 24804837HCID 24804837, compound

Product 1

HCID 24804838HCID 24804838, compoundYield 78%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent

Procedure

A mixture of (E)-3-[4-benzyloxy-4′-(trifluoromethoxy)biphenyl-3-yl]propenoic acid (compound No. 2; 100 mg, 0.241 mmol), platinum oxide (5 mg) and ethanol (10 ml) was stirred for 1 hour under hydrogen atmosphere. The reaction mixture was filtered through celite. The residue obtained by concentration of the filtrate under reduced pressure was washed with methanol under suspension to give the title compound (78 mg, 78.0%) as a white solid.

Workup

  1. filtrationThe reaction mixture was filtered through celite
  2. customThe residue obtained by concentration of the filtrate under reduced pressure
  3. washwas washed with methanol under suspension

Sources & evidence

ORD record
ord-f59355d4bdb64a748d3c6ede5cf6a332
Source dataset
uspto-grants-2011_10
Patent number
US08044236B2

Reaction notes

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