Hydrochloric Acid → HCID 67441634, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl (Z)-3-{4-[4-(tert-butyl)phenoxy]-4′-(trifluoromethoxy)biphenyl-3-yl}propenoate (590 mg, 1.293 mmol), methanol (1 ml), tetrahydrofuran (4 ml) and 2N aqueous sodium hydroxide (1.94 ml) was stirred at 60° C. for 1 hour. The reaction mixture was cooled to room temperature, acidified by addition of 2N hydrochloric acid, and extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give the title compound (550 mg, 93.2%) as a pale yellow oil.

Provenance & Evidence