Potassium Carbonate → HCID 86624482, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-bromo-2-fluorobenzaldehyde (1.07 g, 5.280 mmol), 4-(trifluoromethoxy)phenol (940 mg, 5.280 mmol), potassium carbonate (1.46 g, 10.560 mmol), copper(II) oxide (420 mg, 5.280 mmol) and pyridine (10 ml) was stirred at 180° C. for 6 hours. The reaction mixture was cooled to room temperature and filtered through celite. The filtrate was diluted with water, extracted with water and saturated brine, and dried over anhydrous sodium sulfate. The residue obtained by evaporation of the solvent under reduced pressure was purified by column chromatography on silica gel (n-hexane:ethyl acetate=6:1) to give the title compound (1.58 g, 83.1%) as a brown oil.

Provenance & Evidence