Hydrochloric Acid → HCID 66961011, compound

Participants

Reaction Steps

A mixture of methyl N-benzyl-N-{4-[4-(tert-butyl)benzyloxy]-4′-(trifluoromethoxy)biphenyl-3-yl}oxamate (115 mg, 0.194 mmol), methanol (11.0 ml), 2N aqueous sodium hydroxide (0.2 ml) and tetrahydrofuran (11.0 ml) was stirred at room temperature for 1 hour. The reaction mixture was adjusted to pH 5-6 by addition of 2N hydrochloric acid, and extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous sodium sulfate. The residue obtained by evaporation of the solvent under reduced pressure was purified by column chromatography on silica gel (ethyl acetate methanol=4:1) to give the title compound (75 mg, 67%) as a white solid.

Provenance & Evidence