Sulfuric Acid → HCID 21590270, compound

HRID 1667657Notes

Reaction equation

HRID 1667657 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:12])[CH2:9][C:10]#[N:11])=[CH:4][CH:3]=1.S(=O)(=O)(O)[OH:14]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8](=[O:12])[CH2:9][C:10]([NH2:11])=[O:14])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 1383084-Chlorobenzoylacetonitrile

Product 1

HCID 21590270HCID 21590270, compound

Procedure

The crude 3-(4-chloro-phenyl)-3-oxo-propionitrile obtained above was stirred with 100 mL of sulfuric acid at room temperature for 4 hours. The mixture was poured into 500 mL of ice-water and stirred for 30 minutes. The precipitate was collected by filtration, washed with water and dried under reduced pressure to give 5.73 g of 3-(4-chloro-phenyl)-3-oxo-propionamide as a brown solid which was used in next step without further purification.

Workup

  1. filtrationThe precipitate was collected by filtration
  2. washwashed with water
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-d66bf5267530408b88b1360cb4d2822b
Source dataset
uspto-grants-2011_10
Patent number
US08044213B2

Reaction notes

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