Benzyl Bromide → 4-Benzyloxy-2-fluoro-1-nitrobenzene

Participants

Reaction Steps

To a mixture of 3.14 g (20 mmole) of 3-fluoro-4-nitro-phenol, 100 mL of acetonitrile and 8.3 g (60 mmole) of potassium carbonate was added 2.5 mL (21 mmole) of benzyl bromide. The mixture was heated to reflux for 1 hour, then cooled and concentrated under reduced pressure. The residue was stirred with 100 mL for 30 minutes. The solid was collected by filtration and air dried to give 4.76 g of 4-benzyloxy-2-fluoro-1-nitro-benzene as a yellow solid.

Provenance & Evidence