2-(Bromomethyl)-5-(trifluoromethyl)furan → 3-methyl-1'-{[5-(trifluoromethyl)furan-2-yl]methyl}spiro[furo[2,3-f][1,3]benzoxazole-7,3'-indole]-2,2'(1'H,3H)-dione

HRID 166776Notes

Reaction equation

HRID 166776 reaction equation
[Br:45][CH2:46][c:47]1[o:48][c:49]([C:52]([F:53])([F:54])[F:55])[cH:50][cH:51]1.[CH3:1][n:2]1[c:3](=[O:23])[o:4][c:5]2[c:6]1[cH:7][c:8]1[c:9]([cH:10]2)[C:11]2([CH2:12][O:13]1)[C:14](=[O:22])[NH:15][c:16]1[cH:17][cH:18][cH:19][cH:20][c:21]12.[Cl:56][CH2:57][c:58]1[cH:59][n:60][c:61]([O:62][CH3:63])[n:64][cH:65]1.[NH:24]1[c:25]2[c:26]([cH:27][cH:28][cH:29][cH:30]2)[C:31]2([CH2:32][O:33][c:34]3[cH:35][c:36]4[c:37]([cH:38][c:39]32)[CH2:40][CH2:41][O:42]4)[C:43]1=[O:44]>>[CH3:1][n:2]1[c:3](=[O:23])[o:4][c:5]2[c:6]1[cH:7][c:8]1[c:9]([cH:10]2)[C:11]2([CH2:12][O:13]1)[C:14](=[O:22])[N:15]([CH2:46][c:47]1[o:48][c:49]([C:52]([F:53])([F:54])[F:55])[cH:50][cH:51]1)[c:16]1[cH:17][cH:18][cH:19][cH:20][c:21]12

Participants

5

Reactant 4

HCID 27946052-(Bromomethyl)-5-(trifluoromethyl)furanHCID 216981735-(Chloromethyl)-2-methoxypyrimidineHCID 461955693-methylspiro[furo[2,3-f][1,3]benzoxazole-7,3'-indole]-2,2'(1H,3H)-dioneHCID 592633545,6-dihydro-2H-spiro[benzofuro[6,5-b]furan-3,3'-indolin]-2'-one

Product 1

HCID 593523973-methyl-1'-{[5-(trifluoromethyl)furan-2-yl]methyl}spiro[furo[2,3-f][1,3]benzoxazole-7,3'-indole]-2,2'(1'H,3H)-dione

Sources & evidence

ORD record
ord-5b2a3993f44c4988bfb2f1732e8d7bd9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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