Hydrochloric Acid → HCID 86642847, compound

Participants

Reaction Steps

A mixture of 0.200 g (0.42 mmole) of 4-(3-chloro-phenyl)-2-(5-dimethoxymethyl-4-methoxy-2-nitro-phenylamino)-thiazole-5-carboxylic acid amide (VI.46a), 6 mL of acetonitrile, 2 mL of 6 M hydrochloric acid heated at reflux for 2 hours. The mixture was diluted with 200 mL of ice-water and the purple precipitate was collected by filtration, washed with water, and air dried to give 0.140 g of 4-(3-chloro-phenyl)-2-(5-formyl-4-methoxy-2-nitro-phenylamino)-thiazole-5-carboxylic acid amide (VI.46b).

Provenance & Evidence