反应详情

A mixture of 0.1171 g (0.40 mmole) of 2-amino-4-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide (V.47), 0.0892 g (0.414 mmole) of 4-dimethoxymethyl-2-fluoro-1-nitro-benzene, 6 mL of dimethylformamide and 0.6741 g (2.069 mmole) of cesium carbonate was heated at 60 degrees for 5 hours. The cooled mixture was added to dilute aqueous ammonium chloride. The precipitate was collected by filtration to give 0.1771 g of 2-(5-dimethoxymethyl-2-nitro-phenylamino)-4-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide (VI.47a).

1. temperaturewas heated at 60 degrees for 5 hours
2. filtrationThe precipitate was collected by filtration